"elastix: a toolbox for intensity-based medical image registration"

Stefan Klein*, Marius Staring*, Keelin Murphy, Max A. Viergever and Josien P.W. Pluim

*In alphabetical order. Both authors contributed equally.


Medical image registration is an important task in medical image processing. It refers to the process of aligning data sets, possibly from different modalities (e.g., magnetic resonance (MR) and computed tomography (CT)), different time points (e.g., follow-up scans), and/or different subjects (in case of population studies). A large number of methods for image registration are described in the literature. Unfortunately, there is not one method that works for all applications. We have therefore developed elastix, a publicly available computer program for intensity-based medical image registration. The software consists of a collection of algorithms that are commonly used to solve medical image registration problems. The modular design of elastix allows the user to quickly configure, test, and compare different registration methods for a specific application. The command-line interface enables automated processing of large numbers of data sets, by means of scripting. The usage of elastix for comparing different registration methods is illustrated with three example experiments, in which individual components of the registration method are varied.



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Copyright © 2010 by the authors. Published version © 2010 by IEEE. Personal use of this material is permitted. However, permission to reprint or republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works, must be obtained from the copyright holder.


Source code

The source code of the methods described in this paper can be found in the image registration toolkit elastix, available at http://elastix.isi.uu.nl.

The exact parameter settings used in this paper can be found at the parameter file database of elastix at entry Par0001, Par0002 and Par0003.

BibTeX entry

author = "{Stefan Klein and Marius Staring and Keelin Murphy and Max A. Viergever and Josien P.W. Pluim}",
title = "{elastix: a toolbox for intensity-based medical image registration}",
journal = "{IEEE Transactions on Medical Imaging}",
volume = "{29}",
number = "{1}",
pages = "{196 - 205}",
month = "{January}",
year = "{2010}",

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