"Brain maturation of the adolescent rat cortex and striatum: changes in volume and myelination"

Luam Mengler, Artem Khmelinskii, Michael Diedenhofen, Chrystelle Po, Marius Staring, Boudewijn P.F. Lelieveldt and Mathias Hoehn


Longitudinal studies on brain pathology and assessment of therapeutic strategies rely on a fully mature adult brain to exclude confounds of cerebral developmental changes. Thus, knowledge about onset of adulthood is indispensable for discrimination of developmental phase and adulthood. We have performed a high-resolution longitudinal MRI study at 11.7T of male Wistar rats between 21 days and six months of age, characterizing cerebral volume changes and tissue-specific myelination as a function of age. Cortical thickness reaches final value at 1 month, while volume increases of cortex, striatum and whole brain end only after two months. Myelin accretion is pronounced until the end of the third postnatal month. After this time, continuing myelination increases in cortex are still seen on histological analysis but are no longer reliably detectable with diffusion-weighted MRI due to parallel tissue restructuring processes. In conclusion, cerebral development continues over the first three months of age. This is of relevance for future studies on brain disease models which should not start before the end of month 3 to exclude serious confounds of continuing tissue development.



PDF (10 pages, 3195 kB) click to start download
From publisher link

Copyright © 2014 by the authors. Published version © 2014 by Elsevier Science. Personal use of this material is permitted. However, permission to reprint or republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works, must be obtained from the copyright holder.


BibTeX entry

author = "{Luam Mengler and Artem Khmelinskii and Michael Diedenhofen and Chrystelle Po and Marius Staring and Boudewijn P.F. Lelieveldt and Mathias Hoehn}",
title = "{Brain maturation of the adolescent rat cortex and striatum: changes in volume and myelination}",
journal = "{NeuroImage}",
volume = "{84}",
number = "{1}",
pages = "{35-44}",
month = "{January}",
year = "{2014}",

You are visitor nr. |last modified: 30-09-2013 |webmaster |Copyright 2004-2017 © by Marius Staring