"Automated brain computed tomographic densitometry of early ischemic changes in acute stroke"

Berend C. Stoel, Henk A. Marquering, Marius Staring, Ludo F. Beenen, Cornelis H. Slump, Yvo B. Roos and Charles B. Majoie


The Alberta Stroke Program Early CT score (ASPECTS) scoring method is frequently used for quantifying early ischemic changes (EICs) in patients with acute ischemic stroke in clinical studies. Varying interobserver agreement has been reported, however, with limited agreement. Therefore, our goal was to develop and evaluate an automated brain densitometric method. It divides CT scans of the brain into ASPECTS regions using atlas-based segmentation. EICs are quantified by comparing the brain density between contralateral sides. This method was optimized and validated using CT data from 10 and 63 patients, respectively. The automated method was validated against manual ASPECTS, stroke severity at baseline and clinical outcome after 7 to 10 days (NIH Stroke Scale, NIHSS) and 3 months (modified Rankin Scale). Manual and automated ASPECTS showed similar and statistically significant correlations with baseline NIHSS (R=-0.399 and -0.277, respectively) and with follow-up mRS (R=-0.256 and -0.272), except for the follow-up NIHSS. Agreement between automated and consensus ASPECTS reading was similar to the interobserver agreement of manual ASPECTS (differences <1 point in 73% of cases). The automated ASPECTS method could, therefore, be used as a supplementary tool to assist manual scoring.



PDF (12 pages, 2105 kB) click to start download
From publisher link

Copyright © 2015 by the authors. Published version © 2015 by Society of Photo Optical Instrumentation Engineers. Personal use of this material is permitted. However, permission to reprint or republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works, must be obtained from the copyright holder.


BibTeX entry

author = "{Berend C. Stoel and Henk A. Marquering and Marius Staring and Ludo F. Beenen and Cornelis H. Slump and Yvo B. Roos and Charles B. Majoie}",
title = "{Automated brain computed tomographic densitometry of early ischemic changes in acute stroke}",
journal = "{Journal of Medical Imaging}",
volume = "{2}",
number = "{1}",
pages = "{014004}",
month = "{March}",
year = "{2015}",

You are visitor nr. |last modified: 26-03-2015 |webmaster |Copyright 2004-2017 © by Marius Staring