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"Inter-Station Intensity Standardization for Whole-Body MR Data"

Oleh Dzyubachyk, Marius Staring, Monique Reijnierse, Boudewijn P.F. Lelieveldt and Rob J. van der Geest

Abstract

Purpose. To develop and validate a method for performing inter-station intensity standardization in multi-spectral whole-body MR data.

Methods. Different approaches for mapping the intensity of each acquired image stack into the reference intensity space were developed and validated. The registration strategies included: "direct" registration to the reference station (Strategy 1), "progressive" registration to the neighbouring stations without (Strategy 2) and with (Strategy 3) using information from the overlap regions of the neighbouring stations. For Strategy 3, two regularized modifications were proposed and validated. All methods were tested on two multi-spectral whole-body MR data sets: a multiple myeloma patients data set (48 subjects) and a whole-body MR angiography data set (33 subjects).

Results. For both data sets, all strategies showed significant improvement of intensity homogeneity with respect to vast majority of the validation measures (p < 0.005). Strategy 1 exhibited the best performance, closely followed by Strategy 2. Strategy 3 and its modifications were performing worse, in majority of the cases significantly (p < 0.05).

Conclusions. We propose several strategies for performing inter-station intensity standardization in multi-spectral whole-body MR data. All the strategies were successfully applied to two types of whole-body MR data, and the "direct" registration strategy was concluded to perform the best.

 

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Copyright © 2017 by the authors. Published version © 2017 by . Personal use of this material is permitted. However, permission to reprint or republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works, must be obtained from the copyright holder.

 

BibTeX entry

@article{Dzyubachyk:2017,
author = "{Oleh Dzyubachyk and Marius Staring and Monique Reijnierse and Boudewijn P.F. Lelieveldt and Rob J. van der Geest}",
title = "{Inter-Station Intensity Standardization for Whole-Body MR Data}",
journal = "{Magnetic Resonance in Medicine}",
volume = "{77}",
number = "{1}",
pages = "{422 - 433}",
month = "{January}",
year = "{2017}",
}

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