"Integrating Spatial-Anatomical Regularization and Structure Sparsity into SVM: Improving Interpretation of Alzheimer's Disease Classification"

Zhuo Sun, Yuchuan Qiao, Boudewijn P.F. Lelieveldt and Marius Staring


In recent years, machine learning approaches have been successfully applied to the field of neuroimaging for classification and regression tasks. However, many approaches do not give an intuitive relation between the raw features and the diagnosis. Therefore, they are difficult for clinicians to interpret. Moreover, most approaches treat the features extracted from the brain (for example, voxelwise gray matter concentration maps from brain MRI) as independent variables and ignore their spatial and anatomical relations. In this paper, we present a new Support Vector Machine (SVM)-based learning method for the classification of Alzheimer’s disease (AD), which integrates spatial-anatomical information. In this way, spatial-neighbor features in the same anatomical region are encouraged to have similar weights in the SVM model. Secondly, to make the learned model more interpretable, we introduce a group lasso penalty to induce structure sparsity, which may help clinicians to assess the key regions involved in the disease. For solving this learning problem, we use an accelerated proximal gradient descent approach. We tested our method on the subset of ADNI data selected by Cuingnet et al. (2011) for Alzheimers disease classification, as well as on an independent larger dataset from ADNI. Good classification performance is obtained for distinguishing cognitive normals (CN) vs. AD, as well as on distinguishing between various sub-types (e.g. CN vs. Mild Cognitive Impairment). The model trained on Cuignet’s dataset for AD vs. CN classification was directly used without re-training to the independent larger dataset. Good performance was achieved, demonstrating the generalizability of the proposed methods. For all experiments, the classification results are comparable or better than the state-of-the-art, while the weight map more clearly indicates the key regions related to Alzheimer’s disease.



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Copyright © 2018 by the authors. Published version © 2018 by Elsevier Science. Personal use of this material is permitted. However, permission to reprint or republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works, must be obtained from the copyright holder.


BibTeX entry

author = "{Zhuo Sun and Yuchuan Qiao and Boudewijn P.F. Lelieveldt and Marius Staring}",
title = "{Integrating Spatial-Anatomical Regularization and Structure Sparsity into SVM: Improving Interpretation of Alzheimer's Disease Classification}",
journal = "{NeuroImage}",
volume = "{178}",
pages = "{445 - 460}",
month = "{September}",
year = "{2018}",

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