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"Automatic quantitative analysis of pulmonary vascular morphology in CT images"

Zhiwei Zhai, Marius Staring, Irene Hernandez Giron, Wouter J.H. Veldkamp, Lucia J. Kroft, Maarten K. Ninaber and Berend C. Stoel

Abstract

Purpose: Vascular remodeling is a significant pathological feature of various pulmonary diseases, which may be assessed by quantitative CT imaging. The purpose of this study was therefore to develop and validate an automatic method for quantifying pulmonary vascular morphology in CT images.

Methods: The proposed method consists of pulmonary vessel extraction and quantification. For extracting pulmonary vessels, a graph-cuts based method is proposed which considers appearance (CT intensity) and shape (vesselness from a Hessian-based filter) features, and incorporates distance to the airways into the cost function to prevent false detection of airway walls. For quantifying the extracted pulmonary vessels, a radius histogram is generated by counting the occurrence of vessel radii, calculated from a distance transform based method. Subsequently, two biomarkers, slope α and intercept β, are calculated by linear regression on the radius histogram. A public data set from the VESSEL12 challenge was used to independently evaluate the vessel extraction. The quantitative analysis method was validated using images of a 3D printed vessel phantom, scanned by a clinical CT scanner and a micro-CT scanner (to obtain a gold standard). To confirm the association between imaging biomarkers and pulmonary function, 77 scleroderma patients were investigated with the proposed method.

Results: In the independent evaluation with the public data set, our vessel segmentation method obtained an area under the ROC curve of 0.976. The median radius difference between clinical and micro-CT scans of a 3D printed vessel phantom was 0.062 ± 0.020 mm, with interquartile range of 0.199 ± 0.050 mm. In the studied patient group, a significant correlation between diffusion capacity for carbon monoxide and the biomarkers, α (R=-0.27, p-value=0.018) and β (R=0.321, p-value=0.004), was obtained.

Conclusions: In conclusion, the proposed method was highly accurate, validated with a public data set and a 3D printed vessel phantom data set. The correlation between imaging biomarkers and diffusion capacity in a clinical data set confirmed an association between lung structure and function. This quantification of pulmonary vascular morphology may be helpful in understanding the pathophysiology of pulmonary vascular diseases.

 

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Copyright © 2019 by the authors. Published version © 2019 by American Association of Physicists in Medicine (AAPM). Personal use of this material is permitted. However, permission to reprint or republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works, must be obtained from the copyright holder.

 

BibTeX entry

@article{Zhai:2019,
author = "{Zhiwei Zhai and Marius Staring and Irene Hernandez Giron and Wouter J.H. Veldkamp and Lucia J. Kroft and Maarten K. Ninaber and Berend C. Stoel}",
title = "{Automatic quantitative analysis of pulmonary vascular morphology in CT images}",
journal = "{Medical Physics}",
volume = "{46}",
number = "{9}",
pages = "{3985 - 3997}",
month = "{September}",
year = "{2019}",
}

last modified: 11-09-2019 |webmaster |Copyright 2004-2019 © by Marius Staring