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"MRI visibility of gold fiducial markers for image-guided radiotherapy of rectal cancer"

R.P.J. van den Ende, L.S. Rigter, E.M. Kerkhof, E.L. van Persijn van Meerten, E.C. Rijkmans, D.M.J. Lambregts, B. van Triest, M.E. van Leerdam, M. Staring, C.A.M. Marijnen and U.A. van der Heide

Abstract

BACKGROUND AND PURPOSE: A GTV boost is suggested to result in higher complete response rates in rectal cancer patients, which is attractive for organ preservation. Fiducials may offer GTV position verification on (CB)CT, if the fiducial-GTV spatial relationship can be accurately defined on MRI. The study aim was to evaluate the MRI visibility of fiducials inserted in the rectum.

MATERIAL AND METHODS: We tested four fiducial types (two Visicoil types, Cook and Gold Anchor), inserted in five patients each. Four observers identified fiducial locations on two MRI exams per patient in two scenarios: without (scenario A) and with (scenario B) (CB)CT available. A fiducial was defined to be consistently identified if 3/4 observers labeled that fiducial at the same position on MRI. Fiducial visibility was scored for three MRI sequences.

RESULTS: Fiducial identification was poor in scenario A for all fiducial types. The Visicoil 0.75 and Gold Anchor fiducials were the most consistently identified and were best visible on the T1 3D GRE sequence.

CONCLUSIONS: The Visicoil 0.75 and Gold Anchor fiducials were the most visible fiducials on MRI as they were most consistently identified. The use of a registered (CB)CT and a T1 3D GRE MRI sequence is recommended.

 

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BibTeX entry

@article{vandenEnde:2019,
author = "{R.P.J. van den Ende and L.S. Rigter and E.M. Kerkhof and E.L. van Persijn van Meerten and E.C. Rijkmans and D.M.J. Lambregts and B. van Triest and M.E. van Leerdam and M. Staring and C.A.M. Marijnen and U.A. van der Heide}",
title = "{MRI visibility of gold fiducial markers for image-guided radiotherapy of rectal cancer}",
journal = "{Radiotherapy & Oncology}",
year = "{2019}",
}

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